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KMID : 0043320110340071107
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Archives of Pharmacal Research
2011 Volume.34 No. 7 p.1107 ~ p.1112
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Synthesis and anti-platelet activity of obovatol derivatives
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Kwak Jae-Hwan
Lee Seul
Park Eun-Seok
In Jin-Kyung
Song Ji-Ho
Kim Young-Jin
Choi Nam-Song
Lee Hee-Soon
Yun Yeo-Pyo
Hong Jin-Tae
Kwak Young-Shin
Min Kyung-Hoon
Jung Jae-Kyung
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Abstract
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Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.
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KEYWORD
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Obovatol, Anti-platelet activity, Derivatives, Small molecules
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